Stem Cells

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Recent articles

Small molecule mediators of cell differentiation: Tools to generate tissue from stem cells for screening applications Dec 3, 2008: The development of pharmaceuticals and screening the biological activity of test compounds is a multi-staged process spanning from small molecule design and synthesis, in vitro testing, and compound evaluation in vivo using animal and human trials. The expense of this process escalates as a compound advances further into the development programme. Within each stage there are stringent criteria that must be satisfied before the decision to invest further in the compound and move its development forward is made.

Human Embryonic Stem Cells: Progress in culture and maintenance Sep 29, 2008: The pharmaceutical industry is at a crossroads: Research and Development costs continue to rise, whilst the pipeline of ‘blockbuster’ drugs is looking decidedly sparse for many of the major pharmaceutical companies. This state of affairs is compounded by the high attrition rates (>80%) of drug candidates, when they get to clinical trials. Thus, the major pharmaceutical companies are keen to apply new technologies that allow faster decision making (proceed with development of a drug candidate, or stop at an earlier point) and ultimately increase the number of new medicines that reach the marketplace.