Quest for a new generation of biomarkers using quantitative proteomics
publication date: Sep 29, 2008
Advances in proteomics have constantly altered our understanding of cell biology and biochemistry by providing new approaches and techniques to identify complex proteomes, protein-protein interactions and post-translational modifications. Additionally, proteomic approaches are believed to have enormous potential for discovery of disease biomarkers that can provide diagnostic, prognostic and therapeutic targets and address important problems in clinical and translational research. Unfortunately, to date the development of new assays based on biomarkers discovered by proteomics has been unsuccessful mostly due to low sensitivity and specificity of various candidate biomarkers.
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