The ease in making process analytical measurements (typically spectroscopic) in manufacturing has provided a unique opportunity to obtain up-to-date information for making timely process correction decisions. At-line methods provide near-time information without the need for elaborate process control interfacing upfront. This approach works well for batch processing applications or unit operations when process decisions can be made during a defined operation. Effective use of at-line methods includes the measurement of raw materials, premix batches, or quality check point monitoring before finished product is sent to the finishing lines.
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