The investigation of functional protein-protein interactions has been gaining momentum with recent technological innovations. The high-throughput era in genomics and proteomics research is essentially dependent on technological advancements to drastically increase capacities in both large-scale gathering of data; their interpretation and functional validation, as well as the compilation and storage of data in a standardised format. Contributions of the European Commission-funded ‘Interaction Proteome’, an integrated project in the field, are outlined in this article.
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